Endocrine Abstracts

The adipose tissue is an endocrine organ distributed over multiple depots and broadly categorised into two main subtypes: white adipose tissue which stores energy as lipids and brown adipose tissue which dissipates energy in the form of heat. Adipocytes from the white depots are able to switch from a white to a brown-like phenotype, a process called beiging. This phenomenon is stimulated by cold exposure or sympathetic nervous system activation and is associated with improved ...

Background: Kallmann syndrome (KS) is a genetic disorder associating pubertal failure with anosmia/hyposmia. KS is related to defective neuronal development affecting both the migration of olfactory nerve endings and GnRH neurons. The discovery of several genetic mutations responsible for KS led to the identification of signaling pathways involved in these processes, but the mutations so far identified account for only 30% of cases of KS. Here we attempted to identify new KS r...